Summary: Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation.Telomerase action depends on the telomeric protein TPP1, which recruits telomerase to telomeres and facilitates processive DNA synthesis.Here, we identify separation-of-function long (TPP1-L) and short (TPP1-S) isoforms of TPP1
Hemophilia is an inherited clotting disorder that typically presents as spontaneous hemorrhage or prolonged, excessive bleeding following minor trauma.Abnormalities of the genitourinary tract are a rare manifestation of the disease.Here, we report a case of undiagnosed hemophilia B in a teenage boy presenting with worsening testicular pain and a du
This study aims to assess policies and programs WASDALBIN, constraints in WASDALBIN implement the policy, the steps in implementing policies WASDALBIN PTAIS.The method used descriptive analytic.The unit of analysis of this study determined purposively, is in 3 areas Kopertais I Jakarta, Banten West Java II, and IV Surabaya, which is considered to r
The underdiagnosis of alpha-1 antitrypsin (AAT) deficiency (AATD) has been recognized for many years, yet little progress has been made in treatment of the disease.In this review, we summarize the AATD disease process as well as its diagnosis and treatment by AAT augmentation therapy.AATD is a rare autosomal disease that primarily affects the lungs